2-羟基-2-(4-甲氧基苯基)乙腈合成路线 （共 38 条）
反应条件
(3R,4S)-4-(3,5-dinitrobenzamido)-1,2,3,4-tetrahydrophenanthren-3-yl covalently linked to 3-propyl silica surface in hexane; acetic acid; isopropyl alcohol T=25°C; pH=3.6; Resolution of racemate;
参考文献
Aneja, Ritu; Luthra, Pratibha Mehta; Ahuja, Satinder
Chirality, 2010 , vol. 22, # 5 p. 479 - 485
反应条件
1: 1) HCl(g), 2) 0.1 M aq. HCl / 1) 0 deg C, 1 h, 2) reflux, 3 h 2: 1) K2CO3, 2) 5percent aq. HCl / 1) (CH3)2CO, reflux, 30 min, 2) MeOH, reflux, 3 h View Scheme
参考文献
Malona, John A.; Cariou, Kevin; Spencer, William T.; Frontier, Alison J.
Journal of Organic Chemistry, 2012 , vol. 77, # 4 p. 1891 - 1908
反应条件
1: chromium (VI)-oxide; acetic acid
2: palladium; acetic acid / Hydrogenation
3: aqueous sodium carbonate-solution
View Scheme
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1931 , vol. 269, p. 581,600
Justus Liebigs Annalen der Chemie, 1935 , vol. 519, p. 291,295
反应条件
1: alcoholic ammonia / 60 - 80 °C
2: alcohol; diluted hydrochloric acid
View Scheme
参考文献
Tiemann; Koehler
Chemische Berichte, 1881 , vol. 14, p. 1980
反应条件
chromium(VI) oxide; acetic acid
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1931 , vol. 269, p. 581,600
Justus Liebigs Annalen der Chemie, 1935 , vol. 519, p. 291,295
参考文献
Francis; Davis
Journal of the Chemical Society, 1909 , vol. 95, p. 1406
反应条件
1: aqueous H2SO4
3: LiAlH4 / anschliessendes Erhitzen mit wss. H3PO4
View Scheme
参考文献
Sumrell; Goheen
Journal of the American Chemical Society, 1955 , vol. 77, p. 3805
反应条件
1: ammonia; KOH-solution
2: phenylhydrazine; benzene
3: natrium carbonate
4: alcoholic KOH-solution / beim nachfolgenden Ansaeuern
View Scheme
参考文献
Clarke; Francis
Journal of the Chemical Society, 1911 , vol. 99, p. 323
反应条件
1: aq. H2SO4
2: (i) (alkaline hydrolysis), (ii) aq. HBr, AcOH
3: Br2 / aq. ethanol
View Scheme
参考文献
Nathansohn,G.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1420 - 1422
参考文献
Minovici; Nenitzescu; Angelescu
Bulet. Soc. chim. Romania, vol. 10, p. 149
Chem. Zentralbl., 1929 , vol. 100, # I p. 2187
