1: 26 percent / 2 h / 130 °C 2: NaBH4 / methanol / 0 - 5 °C View Scheme

1: 62 percent / formic acid / methanol / 0.08 h / Ambient temperature 2: 92 percent / sodium borohydride / tetrahydrofuran; H2O / 0.5 h / 0 °C 3: 1.) sodium hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 2 h 4: 70 percent / iodonium di-sym-collidine tetrafluoroborate / acetonitrile / 8 h / Ambient temperature 5: 85 percent / 6M-hydrochloric acid / methanol; H2O / 24 h / Ambient temperature 6: 78 percent / Bu3SnH / AIBN / methanol; toluene / 8 h / 80 °C View Scheme

T=130°C; 2 h;

1: 62 percent / formic acid / methanol / 0.08 h / Ambient temperature 2: 7 percent / sodium borohydride / tetrahydrofuran; H2O / 0.5 h / 0 °C 3: 1.) sodium hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, 0 deg C, 2 h 4: 71 percent / NIS / CHCl3 / 12 h / Ambient temperature 5: 78 percent / Bu3SnH / AIBN / benzene / 3 h / Heating 6: 72 percent / PTSA, pyridine / H2O / 2 h / 100 °C View Scheme

1: 90 percent / chlorohydro(carbonyl)tris(triphenylphosphine)ruthenium HRuCl(CO)(PPh3)3 / 15 h / 150 °C 2: 77 percent / acetic acid / methanol; H2O / 3 h / 25 °C View Scheme