2-(甲氧基甲氧基)三氟甲苯合成路线 （共 5 条）
反应条件
1: α,α,α-trifluoro-o-cresol With sodium hydride in N,N-dimethyl-formamide 1 h; 2: chloromethyl methyl ether in N,N-dimethyl-formamide
参考文献
ABBOTT LABORATORIES; GOMTSYAN, Arthur R.; VOIGHT, Eric A.; BAYBURT, Erol K.; CHEN, Jun; DAANEN, Jerome F.; DIDOMENICO, JR., Stanley; KORT, Michael E.; KYM, Philip R.; MCDONALD, Heath A.; PERNER, Richard J.; SCHMIDT, Robert G.
Patent: WO2010/45401 A1, 2010 ;
Location in patent: Page/Page column 62-63 ;
WO 2010/045401 A1
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C 1.2: 81 percent / tetrahydrofuran / -78 - 20 °C 2.1: 45 percent / aq. AcOH / methanol / 8 h / Heating View Scheme
参考文献
Lai, Guoyin; Guo, Fengfeng; Zheng, Yueqin; Fang, Yang; Song, Haigang; Xu, Kun; Wang, Sujing; Zha, Zhenggen; Wang, Zhiyong
Chemistry - A European Journal, 2011 , vol. 17, # 4 p. 1114 - 1117
反应条件
1: 2-methoxymethoxy-1-trifluoromethylbenzene With n-butyllithium in tetrahydrofuran; hexanes T=-20 - 5°C; 2: carbon dioxide in tetrahydrofuran; hexanes T=-20 - -10°C; 3: With hydrogenchloride in tetrahydrofuran; hexanes; water T=-20°C;
参考文献
ABBOTT LABORATORIES; GOMTSYAN, Arthur R.; VOIGHT, Eric A.; BAYBURT, Erol K.; CHEN, Jun; DAANEN, Jerome F.; DIDOMENICO, Stanley, Jr.; KORT, Michael E.; KYM, Philip R.; MCDONALD, Heath A.; PERNER, Richard J.; SCHMIDT, Robert G.
Patent: WO2010/45402 A1, 2010 ;
Location in patent: Page/Page column 61-62 ;
WO 2010/045402 A1
反应条件
1: 56 percent / potassium tert-butoxide; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 2: 90 percent / boron trifluoride-diethyl ether / methanol / 15 h / 25 °C View Scheme
参考文献
Marzi, Elena; Mongin, Florence; Spitaleri, Andrea; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 15 p. 2911 - 2915
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1.75 h / -70 °C / Inert atmosphere 1.2: 0.5 h / 20 °C 2.1: hydrogenchloride; water / hexane; tetrahydrofuran / 16 h / 60 °C 3.1: N-bromosuccinmide / acetonitrile / 1 h / 0 °C View Scheme
