5,5-二甲基-4-苯基-1,3-恶唑烷-2-酮合成路线 (共 6 条)
反应条件
1: tetrahydrofuran 2: t-BuONa / tetrahydrofuran View Scheme
参考文献
Birman, Vladimir B.; Jiang, Hui; Li, Ximin; Guo, Lei; Uffman, Eric W.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6536 - 6537
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Hofmann,H. et al.
Chemische Berichte, 1971 , vol. 104, p. 2134 - 2142
反应条件
1: (i) benzene, (ii) (heating) 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Hofmann,H. et al.
Chemische Berichte, 1971 , vol. 104, p. 2134 - 2142
反应条件
(R)-BTM; sodium sulfate; N-ethyl-N,N-diisopropylamine in chloroform T=20°C; 12 h;
参考文献
Birman, Vladimir B.; Jiang, Hui; Li, Ximin; Guo, Lei; Uffman, Eric W.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6536 - 6537
反应条件
(R)-BTM; sodium sulfate; N-ethyl-N,N-diisopropylamine in chloroform T=20°C; 12 h;
参考文献
Birman, Vladimir B.; Jiang, Hui; Li, Ximin; Guo, Lei; Uffman, Eric W.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6536 - 6537
反应条件
1: 5,5-dimethyl-4-phenyl-oxazolidin-2-one With (R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in 1,1-dimethylpropan-1-ol T=0°C; Resolution of racemate; 2: isobutyric anhydride in 1,1-dimethylpropan-1-ol T=0°C; 22 h; Resolution of racemate; Reagent/catalystTime; enantioselective reaction;
参考文献
Yang, Xing; Bumbu, Valentina D.; Liu, Peng; Li, Ximin; Jiang, Hui; Uffman, Eric W.; Guo, Lei; Zhang, Wei; Jiang, Xuntian; Houk; Birman, Vladimir B.
Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17605 - 17612