(6-氯-2-吡啶基)甲醇合成路线 （共 13 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-45 - 0°C; 1.5 h; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
LG LIFE SCIENCES, LTD.
Patent: WO2007/58482 A1, 2007 ;
Location in patent: Page/Page column 47-48 ;
WO 2007/058482 A1
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in dichloromethane T=40°C; 1.5 h; 2: With acetic anhydride T=100°C; 1 h; 3: With sodium hydroxide; water in methanol T=0°C; 0.5 h;
参考文献
Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki
Patent: US2009/82403 A1, 2009 ;
Location in patent: Page/Page column 100 ;
反应条件
hydrogenchloride 1.5 h; Heating;
参考文献
Barnes, John H.; Hartley, Frank R.; Jones, Christopher E. L.
Tetrahedron, 1982 , vol. 38, # 22 p. 3277 - 3280
反应条件
lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
sodium hydroxide in tetrahydrofuran; water; ethyl acetate
反应条件
1: H2SO4 / 20 - 110 °C 2: 815 mg / K2CO3 / methanol; H2O / 0.25 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 23 p. 8576 - 8581
反应条件
potassium carbonate in water Hydrolysis; Heating;
参考文献
Journal of Organic Chemistry, , vol. 65, # 23 p. 7718 - 7722
反应条件
1: With thionyl chloride in toluene T=0 - 20°C; 2: With water; sodium hydrogencarbonate in toluene
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2007/105904 A1, 2007 ;
Location in patent: Page/Page column 99-100 ;
反应条件
1: thionyl chloride / dichloromethane / 20 h / 0 - 26 °C 2: dimethyl sulfoxide / 2.25 h / 0 - 10 °C View Scheme
参考文献
HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian
Patent: WO2011/47156 A1, 2011 ;
WO 2011/047156 A1
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide 1.5 h; Ambient temperature;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
