2-甲氨基-3-硝基-6-氯吡啶合成路线 （共 9 条）
反应条件
sodium carbonate in ethanol T=20°C; Amination; 8 h;
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
sodium chloride; sodium carbonate; methylamine in ethanol
反应条件
sodium carbonate; methylamine in toluene
反应条件
in ethanol; water T=5 - 10°C; 4 h;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 6 p. 501 - 506
反应条件
1: 91 percent / methanol / 3 h / 20 °C 2: 92 percent / H2 / 10percent Pd/C / dioxane / 5 h / 80 °C View Scheme
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
hydrogenchloride; zinc in acetic acid
T=8 - 10°C; 0.5 h;
参考文献
MERCK SHARP and DOHME CORP.; ARRINGTON, Kenneth, L.; DUDKIN, Vadim; LAYTON, Mark, E.; PERO, Joseph, E.; REIF, Alexander, J.
Patent: WO2011/156245 A2, 2011 ;
Location in patent: Page/Page column 25-26 ;
反应条件
1: 37percent HCl, zinc powder / acetic acid / 0.5 h / 8 - 10 °C
2: 53 percent / CHCl3 / 5 h / Heating
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; LAYTON, Mark, E.; PERO, Joseph, E.; RODZINAK, Kevin, J.; ROSSI, Michael, A.
Patent: WO2011/34741 A1, 2011 ;
WO 2011/034741 A1
反应条件
sodium chloride; sodium methylate in methanol
参考文献
Sankyo Company, Limited
Patent: US5624935 A1, 1997 ;
反应条件
in methanol
T=20°C; Methoxylation; 3 h;
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
