N'-羟基-1-苯并噻吩-2-甲脒合成路线 （共 3 条）
反应条件
hydroxylamine hydrochloride; sodium carbonate in ethanol; water T=20°C; 24 h;
参考文献
Zhou, Yuefen; Vu, Khang; Chen, Yongsheng; Pham, John; Brady, Thomas; Liu, Gang; Chen, Jinhua; Nam, Joonwoo; Murali Mohan Reddy; Au, Qingyan; Yoon, Il Sang; Tremblay, Marie-Helene; Yip, Gary; Cher, Charmian; Zhang, Bin; Barber, Jack R.; Ng, Shi Chung
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3128 - 3135
反应条件
1: 2.49 g / HCOOH; NH2OH*HCl / 1 h / Heating 2: NH2OH*HCl; Na2CO3 / ethanol; H2O / 24 h / 20 °C View Scheme
参考文献
Koch, Uwe; Attenni, Barbara; Malancona, Savina; Colarusso, Stefania; Conte, Immacolata; Di Filippo, Marcello; Harper, Steven; Pacini, Barbara; Giomini, Claudia; Thomas, Steven; Incitti, Ilario; Tomei, Licia; De Francesco, Raffaele; Altamura, Sergio; Matassa, Victor G.; Narjes, Frank
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1693 - 1705
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / -78 - -20 °C 1.2: tetrahydrofuran; hexane / 0.33 h / -78 °C 2.1: 2.49 g / HCOOH; NH2OH*HCl / 1 h / Heating 3.1: NH2OH*HCl; Na2CO3 / ethanol; H2O / 24 h / 20 °C View Scheme
参考文献
Koch, Uwe; Attenni, Barbara; Malancona, Savina; Colarusso, Stefania; Conte, Immacolata; Di Filippo, Marcello; Harper, Steven; Pacini, Barbara; Giomini, Claudia; Thomas, Steven; Incitti, Ilario; Tomei, Licia; De Francesco, Raffaele; Altamura, Sergio; Matassa, Victor G.; Narjes, Frank
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1693 - 1705
