1-甲酰基-4-氧代-4H-羟基喹啉-3-羧酸乙酯合成路线 （共 2 条）
反应条件
trichlorophosphate Vilsmeier formylation; 1 h; regioselective reaction;
参考文献
Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780
反应条件
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / 0.5 h / -78 - -60 °C / Inert atmosphere 1.2: -60 - -20 °C / Inert atmosphere 1.3: 16 h / Reflux 2.1: trichlorophosphate / 1 h View Scheme
参考文献
Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780
