anhydrous tetramethylammonium chloride; trichlorophosphate T=30 - 103.5°C; 36 h;

1: N-(2,6-dichloro-4-pyridinyl)-2,2-dimethylpropanamide With n-butyllithium in tetrahydrofuran; hexanes T=-70 - -60°C; 1.5 h; Inert atmosphere; 2: 3-dimethylaminoacrylaldehyde in tetrahydrofuran; hexanes T=-70 - 20°C; Product distribution / selectivity;

1.1: potassium tert-butylate / isopropyl alcohol / 30 - 40 °C / Inert atmosphere 1.2: 4 h / 35 - 78 °C / Inert atmosphere 2.1: anhydrous tetramethylammonium chloride; trichlorophosphate / 36 h / 30 - 103.5 °C View Scheme

1.1: triethylamine / dichloromethane / Cooling with ice 2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.5 h / -70 - -60 °C / Inert atmosphere 2.2: -70 - 20 °C View Scheme