in dichloromethane 4 h; Ambient temperature;

1.1: trimethyl orthoformate; sulfuric acid / tetrahydrofuran / 0.42 h / 20 °C / |Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.13 h / -110 - 20 °C / |Inert atmosphere 2.2: -78 °C / |Inert atmosphere 2.3: 12 h / |Inert atmosphere 3.1: tert-butyl alcohol; water / 1 h / 23 °C / |Inert atmosphere View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / |Inert atmosphere 2: potassium carbonate / methanol / 15 h / 20 °C / |Inert atmosphere 3: triethylamine / dichloromethane / 12 h / 0 - 20 °C / |Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C / |Inert atmosphere 5: tert-butyl alcohol; water / 1 h / 23 °C / |Inert atmosphere View Scheme

in water; tert-butyl alcohol T=23°C; 1 h; Inert atmosphere; chemoselective reaction;

in water; tert-butyl alcohol T=23°C; 1 h; Inert atmosphere; chemoselective reaction;

in water; tert-butyl alcohol T=23°C; 1 h; Inert atmosphere; chemoselective reaction;

in water; tert-butyl alcohol T=23°C; 1 h; Inert atmosphere; chemoselective reaction;

in water; tert-butyl alcohol T=23°C; 1 h; Inert atmosphere; chemoselective reaction;

in water; tert-butyl alcohol T=23°C; 1 h; Inert atmosphere; chemoselective reaction;

1: 1 g / polyphosphoric acid / 4 h / 140 °C 2: H2 / PtO2 / ethanol / 20 h / 1551.4 Torr View Scheme