6,7-二甲氧基-3,4-二氢异喹啉合成路线 （共 75 条）
反应条件
2: 100 percent / KOH / ethanol / 5 h / Ambient temperature
3: 34 percent / η5-cyclopentadienyl dicarbonyl cobalt / m-xylene / 8 h / Heating; Irradiation
4: 100 percent / trifluoroacetic acid / CCl4 / 1.5 h
View Scheme
参考文献
Hillard, Russel L.; Parnell, Carol A.; Vollhardt, K. Peter C.
Tetrahedron, 1983 , vol. 39, # 6 p. 905 - 912
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: BF3*OEt2 / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.3: 40 percent / tetrahydrofuran / 2 h / -78 - 20 °C
2.1: KF / methanol / 16 h / 20 °C
3.1: 228 mg / DCC; DMAP / CH2Cl2 / 15 h / 20 °C
4.1: 82 percent / η5-C5Me5RuCl(1,5-cyclooctadiene) / 1,2-dichloro-ethane / 0.5 h / 20 °C
View Scheme
参考文献
Yamamoto, Yoshihiko; Kinpara, Keisuke; Saigoku, Tomoaki; Nishiyama, Hisao; Itoh, Kenji
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 9 p. 1287 - 1294
反应条件
formic acid
T=90°C; 24 h;
参考文献
Siegfried, Marc-Andre; Hilpert, Hans; Rey, Max; Dreidind, Andre S.
Helvetica Chimica Acta, 1980 , vol. 63, # 4 p. 938 - 961
反应条件
2: NaBH4
View Scheme
参考文献
Hutchins, Michael; Sainsbury, Malcolm; Scopes, David I. C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2059 - 2064
反应条件
sodium tetrahydroborate
Multistep reaction;
参考文献
Majeed, Amera J.; Sainsbury, Malcolm; Hall, Stephen A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 4 p. 833 - 837
反应条件
1.1: Et2O*BF3 / tetrahydrofuran / 0.5 h / -23 °C
1.2: 61 percent / diethyl ether / 15 h / -23 °C
2.1: 58 percent / AgOAc / CH2Cl2 / 14 h / 20 °C
3.1: 66 percent / H2 / Rh/C / acetic acid; methanol / 192 h / 20 °C
View Scheme
参考文献
Knoelker, Hans-Joachim; Agarwal, Sameer
Tetrahedron Letters, 2005 , vol. 46, # 7 p. 1173 - 1175
参考文献
Buck; Ide
Journal of the American Chemical Society, 1938 , vol. 60, p. 2101
参考文献
Pelletier, Jeffrey C.; Cava, Michael P.
Synthesis, 1987 , # 5 p. 474 - 477
反应条件
in diethyl ether
T=25°C; 6 h; Irradiation;
参考文献
Hegedus; McGuire; Schultze; et al.
Journal of the American Chemical Society, 1984 , vol. 106, # 9 p. 2680 - 2687
反应条件
1: 89 percent / toluene / 2 h / Heating
2: 76 percent / aq. KOH / acetonitrile; H2O / 3 h / 20 °C
3: 71 percent / aq. silver nitrate / acetonitrile; H2O / 16 h / 20 °C
4: 95 percent / Na; liq. NH3 / tetrahydrofuran / 0.5 h / -78 °C
5: 98 percent / Me3SiCl; NaI / acetonitrile / 24 h / 20 °C
6: 40 percent / t-BuOK / dimethylsulfoxide / 2 h / 50 °C
View Scheme
参考文献
Pauvert, Mickael; Collet, Sylvain; Guingant, Andre
Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4203 - 4206
