1,3-苯并二噁茂-4-甲酸甲酯合成路线 （共 10 条）
反应条件
1: 2,3-dihydroxybenzoic acid methyl ester With potassium fluoride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: 1,1-dibromomethane in N,N-dimethyl-formamide T=120°C; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 4 p. 871 - 887
反应条件
1: 2,3-dihydroxybenzoic acid methyl ester With potassium fluoride in N,N-dimethyl-formamide T=20°C; 0.5 h; Inert atmosphere; 2: dichloromethane in N,N-dimethyl-formamide T=20 - 120°C; Inert atmosphere;
参考文献
Steroids, , vol. 75, # 12 p. 967 - 973
反应条件
sulfuric acid 15 h; Reflux;
参考文献
WO2010/86278 A1, ;
Page/Page column 16 ;
WO 2010/086278 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 5 h;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 59, # 2 p. 635 - 644
反应条件
1.1: 40 percent / H2SO4 / 24 h / 60 °C 2.1: KF / dimethylformamide / 0.5 h / 20 °C 2.2: 80 percent / dimethylformamide / 3 h / 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 4 p. 871 - 887
反应条件
methanol; diethyl ether
参考文献
Chemische Berichte, , vol. 91, p. 36,38
反应条件
1: 73 percent / KOH / methanol; H2O / 2 h / 20 °C 2: 77 percent / DPPA; Et3N / dioxane / 5 h / Heating View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: With methanol; potassium hydroxide T=20°C; 3 h; 2: With hydrogenchloride in water pH=3.5; Cooling with ice;
参考文献
Huang, Zhiqiang; Liu, Yuxiu; Li, Yongqiang; Xiong, Lixia; Cui, Zhipeng; Song, Hongjian; Liu, Hongli; Zhao, Qiqi; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2011 , vol. 59, # 2 p. 635 - 644
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Chemische Berichte, , vol. 91, p. 36,38
反应条件
1: 73 percent / KOH / methanol; H2O / 2 h / 20 °C 2: 77 percent / DPPA; Et3N / dioxane / 5 h / Heating 3: 91 percent / aq. HCl / ethanol / 20 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 4 p. 871 - 887
