3,5-二羟基-4-碘苯甲酸甲酯合成路线 （共 4 条）
反应条件
sulfuric acid T=60°C; 3.75 h;
参考文献
Basilea Pharmaceutica AG
Patent: US6821980 B1, 2004 ;
Location in patent: Page column 21 ;
反应条件
iodine; sodium hydrogencarbonate in tetrahydrofuran; water T=2 - 8°C; 1.5 h; Large scale reaction;
参考文献
Berliner, Martin A.; Cordi, Eric M.; Dunetz, Joshua R.; Price, Kristin E.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 180 - 187
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine in N,N-dimethyl acetamide T=38°C; Sonogashira coupling; P=1277.21 Torr; 20 h; Inert atmosphereLarge scale reaction;
参考文献
Berliner, Martin A.; Cordi, Eric M.; Dunetz, Joshua R.; Price, Kristin E.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 180 - 187
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide T=24°C; P=1018.63 Torr; 25 h; Inert atmosphere;
参考文献
Berliner, Martin A.; Cordi, Eric M.; Dunetz, Joshua R.; Price, Kristin E.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 180 - 187
