1: With n-butyllithium in tetrahydrofuran; hexane T=-78 - -70°C; 0.666667 h; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane T=-70 - 20°C; 3: With hydrogenchloride; water T=0°C;

1.1: 73 percent / K2CO3 / acetone / 8 h / Heating 2.1: BuLi / tetrahydrofuran; hexane / 2 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 3.1: 4.8 g / aq. HCl / tetrahydrofuran; hexane / 1 h / 0 °C View Scheme

1.1: 73 percent / K2CO3 / acetone / 8 h / Heating 2.1: BuLi / tetrahydrofuran; hexane / 2 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 3.1: 4.8 g / aq. HCl / tetrahydrofuran; hexane / 1 h / 0 °C View Scheme