1: With n-butyllithium in tetrahydrofuran; hexane T=-78 - -70°C; 0.666667 h; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane T=-70 - 20°C; 3: With hydrogenchloride; water T=0°C;
参考文献
Basilea Pharmaceutica AG
Patent: US6821980 B1, 2004 ;
Location in patent: Page column 28 ;