4-(4-溴-2-氟苯甲基)吗啉合成路线 （共 3 条）
反应条件
1: in chloroform T=58 - 60°C; 1 h; Sealed tube; 2: With sodium tris(acetoxy)borohydride in chloroform T=58 - 60°C; 16 h; Sealed tube;
参考文献
UNIVERSITY OF DUNDEE; GILBERT, Ian Hugh; NORCROSS, Neil; BARAGANA RUIBAL, Beatriz; PORZELLE, Achim
Patent: WO2013/153357 A1, 2013 ;
Location in patent: Page/Page column 54; 55 ;
反应条件
in acetonitrile T=20°C; 16 h;
参考文献
GALAPAGOS NV; MENET, Christel, Jeanne, Marie; BLANC, Javier; HODGES, Alastair, James; BURLI, Roland, Werner; BRECCIA, Perla; BLACKABY, Wesley, Peter; VAN ROMPAEY, Luc, Juliaan, Corina; FLETCHER, Stephen, Robert
Patent: WO2010/10184 A1, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/010184 A1
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=90°C; 16 h;
参考文献
UNIVERSITY OF DUNDEE; GILBERT, Ian Hugh; NORCROSS, Neil; BARAGANA RUIBAL, Beatriz; PORZELLE, Achim
Patent: WO2013/153357 A1, 2013 ;
Location in patent: Page/Page column 54; 55 ;
