4,6-二甲基-2-氧-2H-吡喃-5-甲酸乙酯合成路线 （共 36 条）
反应条件
sodium ethanolate in ethanol
Yield given;
参考文献
Quast, Helmut; Berneth, Claus-Peter
Chemische Berichte, 1983 , vol. 116, # 4 p. 1345 - 1363
参考文献
Wiley et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 311
参考文献
Panizzi
Gazzetta Chimica Italiana, 1942 , vol. 72, p. 423,428
参考文献
Panizzi
Gazzetta Chimica Italiana, 1942 , vol. 72, p. 423,428
反应条件
1: 95 percent / NaOH / H2O / 1 h / 70 °C
2: 85 percent / Ac2O / 0.5 h / 70 °C
3: 80 percent / diethyl ether / 12 h / 25 °C
4: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h
5: 100 percent / HBr / acetic acid / 5 h / Heating
6: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature
7: NaOH / H2O / 1.75 h / 100 °C
View Scheme
参考文献
Jung; Lowe III; Lyster; et al.
Tetrahedron, 1984 , vol. 40, # 22 p. 4751 - 4766
反应条件
1: 95 percent / NaOH / H2O / 1 h / 70 °C
2: 85 percent / Ac2O / 0.5 h / 70 °C
3: 80 percent / diethyl ether / 12 h / 25 °C
4: 2.) Ag2O, MgSO4 / 1.) mesytilene, reflux, 74 h; 2.) RT, 12 h
5: 87 percent / HBr / acetic acid / 4 h / Heating
View Scheme
参考文献
Jung; Lowe III; Lyster; et al.
Tetrahedron, 1984 , vol. 40, # 22 p. 4751 - 4766
