3-甲氧基-2-硝基苯乙酮合成路线 （共 15 条）
反应条件
nitric acid T=20°C; 54 h;
参考文献
Gabriele, Bartolo; Mancuso, Raffaella; Salerno, Giuseppe; Ruffolo, Giuseppe; Plastina, Pierluigi
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6873 - 6877
反应条件
1: diethyl malonate in diethyl ether; ethanol T=20°C; Reflux; 2: 3-methoxy-2-nitro benzoyl chloride in diethyl ether; ethanol 18 h; Reflux;
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
Location in patent: Page/Page column 47; 48 ;
反应条件
1: 3-methoxy-2-nitro benzoyl chloride With magnesium; diethyl malonate in diethyl ether; ethanol T=20°C; 18 h; Reflux; 2: With hydrogenchloride in water 3: acetic acid With sulfuric acid in water 5 h; Reflux;
参考文献
SANOFI
Patent: US2012/129864 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
potassium carbonate in dimethyl sulfoxide T=50°C; 20 h;
参考文献
Okuro, Kazumi; Gurnham, Joanna; Alper, Howard
Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4715 - 4720
反应条件
1: tetrahydrofuran 2: 1.) oxalyl chloride, DMSO, 2.) NEt3 / 1.) CH2Cl2 View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
potassium hydroxide 1.) r.t., 30 min, 2.) 30 min;
参考文献
Muller; Back
Archiv der Pharmazie, 1983 , vol. 316, # 8 p. 707 - 712
反应条件
1.1: thionyl chloride / 3 h / 75 °C 2.1: diethyl ether; ethanol / 20 °C / Reflux 2.2: 18 h / Reflux View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine 1.) CH2Cl2; Multistep reaction;
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
chlorobenzene beim Erhitzen des Reaktionsprodukts mit wss. HCl und Essigsaeure;
参考文献
Spada; Casini
Gazzetta Chimica Italiana, 1950 , vol. 80, p. 642,647
反应条件
1: alkali 2: water; nitric acid View Scheme
参考文献
Simpson et al.
Journal of the Chemical Society, 1945 , p. 646,655
