1: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 2: n-BuLi / tetrahydrofuran / -78 - 0 °C 3: TBAF / tetrahydrofuran / Ambient temperature 4: Dess-Martin reagent / CH2Cl2 / 0 °C 5: 93 percent / Ni(acac)2, PPh3, DIBAL-H, 1,3-cyclohexadiene / toluene / 1 h / Ambient temperature 6: imidazole / dimethylformamide 7: O3 / CH2Cl2 / -78 °C 8: t-BuOK / tetrahydrofuran / Ambient temperature 10: TBAF / tetrahydrofuran 11: 95 percent / pyridine; CH2Cl2 / Ambient temperature 12: DOWEX 50WX8 / methanol / 50 °C 13: Et3N / CH2Cl2 14: PPTS / CH2Cl2 / Ambient temperature 15: TBAF / tetrahydrofuran / Ambient temperature 16: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 17: NaH / tetrahydrofuran / Ambient temperature 18: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 19: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 20: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: O3 / CH2Cl2 / -78 °C 2: t-BuOK / tetrahydrofuran / Ambient temperature 4: TBAF / tetrahydrofuran 5: 95 percent / pyridine; CH2Cl2 / Ambient temperature 6: DOWEX 50WX8 / methanol / 50 °C 7: Et3N / CH2Cl2 8: PPTS / CH2Cl2 / Ambient temperature 9: TBAF / tetrahydrofuran / Ambient temperature 10: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 11: NaH / tetrahydrofuran / Ambient temperature 12: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 13: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 14: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: 53 percent / Ni(acac)2, PPh3, DIBAL-H, 1,3-cyclohexadiene / tetrahydrofuran / 15 h / Ambient temperature 2: 95 percent / pyridine; CH2Cl2 / Ambient temperature 3: DOWEX 50WX8 / methanol / 50 °C 4: Et3N / CH2Cl2 5: PPTS / CH2Cl2 / Ambient temperature 6: TBAF / tetrahydrofuran / Ambient temperature 7: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 8: NaH / tetrahydrofuran / Ambient temperature 9: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 10: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 11: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: 95 percent / pyridine; CH2Cl2 / Ambient temperature 2: DOWEX 50WX8 / methanol / 50 °C 3: Et3N / CH2Cl2 4: PPTS / CH2Cl2 / Ambient temperature 5: TBAF / tetrahydrofuran / Ambient temperature 6: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 7: NaH / tetrahydrofuran / Ambient temperature 8: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 9: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 10: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: Dess-Martin reagent / CH2Cl2 / 0 °C 2: 53 percent / Ni(acac)2, PPh3, DIBAL-H, 1,3-cyclohexadiene / tetrahydrofuran / 15 h / Ambient temperature 3: 95 percent / pyridine; CH2Cl2 / Ambient temperature 4: DOWEX 50WX8 / methanol / 50 °C 5: Et3N / CH2Cl2 6: PPTS / CH2Cl2 / Ambient temperature 7: TBAF / tetrahydrofuran / Ambient temperature 8: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 9: NaH / tetrahydrofuran / Ambient temperature 10: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 11: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 12: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: 95 percent / DIBAL-H / toluene / -78 °C 2: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 3: n-BuLi / tetrahydrofuran / -78 - 0 °C 4: TBAF / tetrahydrofuran / Ambient temperature 5: Dess-Martin reagent / CH2Cl2 / 0 °C 6: 93 percent / Ni(acac)2, PPh3, DIBAL-H, 1,3-cyclohexadiene / toluene / 1 h / Ambient temperature 7: imidazole / dimethylformamide 8: O3 / CH2Cl2 / -78 °C 9: t-BuOK / tetrahydrofuran / Ambient temperature 11: TBAF / tetrahydrofuran 12: 95 percent / pyridine; CH2Cl2 / Ambient temperature 13: DOWEX 50WX8 / methanol / 50 °C 14: Et3N / CH2Cl2 15: PPTS / CH2Cl2 / Ambient temperature 16: TBAF / tetrahydrofuran / Ambient temperature 17: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 18: NaH / tetrahydrofuran / Ambient temperature 19: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 20: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 21: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: DOWEX 50WX8 / methanol / 50 °C 2: Et3N / CH2Cl2 3: PPTS / CH2Cl2 / Ambient temperature 4: TBAF / tetrahydrofuran / Ambient temperature 5: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 6: NaH / tetrahydrofuran / Ambient temperature 7: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 8: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 9: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 2: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 3: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 2: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme

1: PPTS / CH2Cl2 / Ambient temperature 2: TBAF / tetrahydrofuran / Ambient temperature 3: PCC, 4 Angstroem molecular sieves, NaOAc / CH2Cl2 / 0 °C 4: NaH / tetrahydrofuran / Ambient temperature 5: 92 percent / (S)-binaphthol, LiAlH4 / ethanol; tetrahydrofuran / -100 - -78 °C 6: 93 percent / acetic acid / H2O; tetrahydrofuran / 40 °C 7: 95 percent / 1N NaOH / methanol; tetrahydrofuran / Ambient temperature View Scheme