1-溴-3-氯-5-氟苯合成路线 （共 16 条）
反应条件
n-butyllithium in hexane
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US6566372 B1, 2003 ;
反应条件
1.1: lithium diisopropyl amide; N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 2 h / -78 - 0 °C 1.2: 0 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28952 A1, 2012 ;
反应条件
1: 1.) NaH, NMP / 2.) from 110 deg C to 115 deg C, 30 h 2: 97 percent / aq. NaOH / 18 h / 95 - 100 °C View Scheme
参考文献
Kowalczyk, Bruce A.
Synthesis, 1997 , # 12 p. 1411 - 1414
反应条件
in methanol T=0 - 40°C; 3 h;
参考文献
Roche Palo Alto LLC
Patent: US2006/25462 A1, 2006 ;
Location in patent: Page/Page column 16-17 ;
反应条件
sodium methylate in methanol; dichloromethane
参考文献
Jones, Lyn Howard; Mowbray, Charles Eric; Price, David Anthony; Selby, Matthew Duncan; Stupple, Paul Anthony
Patent: US2003/100554 A1, 2003 ;
反应条件
sodium hydride in 1-methyl-pyrrolidin-2-one; mineral oil T=20 - 120°C; 10 h;
参考文献
AMIRA PHARMACEUTICALS, INC.
Patent: US2010/4331 A1, 2010 ;
Location in patent: Page/Page column 15 ;
