(2R)-2-氨基-2-苯基丁酸合成路线 （共 5 条）
反应条件
1: With hydrogenchloride; water in 1,4-dioxane T=80°C; 48 h; 2: With ammonium hydroxide in water
参考文献
Berlin, Jacob M.; Fu, Gregory C.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 37 p. 7048 - 7050
反应条件
water; sodium hydroxide T=130°C; 48 h; Autoclave;
参考文献
Oroxcell; Alexis Denis
Patent: US2009/197924 A1, 2009 ;
Location in patent: Page/Page column 12 ;
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 61 ;
反应条件
1: nBu4NI, KOH/K2CO3 melted / CH2Cl2 / 12 h / Ambient temperature 2: H2 / Pd(OH)2/C / methanol / 760 Torr View Scheme
参考文献
O'Donnell, Martin J.; Fang, Zhiqiang; Ma, Xiaojun; Huffman, John C.
Heterocycles, 1997 , vol. 46, # 1 p. 617 - 630
反应条件
T=37°C; Mycobacterium neoaurum ATCC 25795, pH 8-8.5; Title compound not separated from byproducts;
参考文献
Kaptein; Boesten; Broxterman; Peters; Schoemaker; Kamphuis
Tetrahedron Asymmetry, 1993 , vol. 4, # 6 p. 1113 - 1116
