(S)-5-(吡咯烷-2-基)-1H-四唑合成路线 （共 6 条）
反应条件
diethylaluminium azide in xylene T=85°C; 9 h;
参考文献
Aureggi, Valentina; Sedelmeier, Gottfried
Angewandte Chemie - International Edition, 2007 , vol. 46, # 44 p. 8440 - 8444
反应条件
hydrogen; palladium on activated charcoal
参考文献
Hartikka, Antti; Arvidsson, Per I.
European Journal of Organic Chemistry, 2005 , # 20 p. 4287 - 4295
反应条件
1: With hydrogenchloride in water; toluene; xylene T=0°C; pH=1; 2: With potassium carbonate in water; toluene; xylene
参考文献
WO2007/9716 A1, ;
Page/Page column 29-30 ;
反应条件
1: 97 percent / cyanuric chloride / dimethylformamide / 4 h / 0 - 20 °C 2: triethylamine hydrochloride; sodium azide / toluene / 24 h / 95 °C 3: 1.50 g / hydrogen / Pd/C / ethyl acetate; acetic acid; ethanol / 80 °C / 750.06 Torr View Scheme
参考文献
Synlett, , # 6 p. 889 - 892
反应条件
1: 96 percent / di-tert-butyl dicarbonate; NH4HCO3; pyridine / acetonitrile / 5 h / 20 °C 2: 97 percent / cyanuric chloride / dimethylformamide / 4 h / 0 - 20 °C 3: triethylamine hydrochloride; sodium azide / toluene / 24 h / 95 °C 4: 1.50 g / hydrogen / Pd/C / ethyl acetate; acetic acid; ethanol / 80 °C / 750.06 Torr View Scheme
参考文献
Synlett, , # 6 p. 889 - 892
反应条件
1: 90 percent / aq. NaOH / 2 h / 5 °C 2: 96 percent / di-tert-butyl pyrocarbonate; ammonium hydrogencarbonate; pyridine / acetonitrile / 68 h 3: 96 percent / cyanuric chloride / dimethylformamide / 79 h / 20 °C 4: 98 percent / NaN3; ZnBr2 / propan-2-ol; H2O / 24 h / Heating 5: 95 percent / H2 / Pd/C / acetic acid; H2O / 72 h View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 4287 - 4295
