(S)-4,7alpha-二甲基-2,3,7,7alpha-四氢-6H-茚-1,5-二酮合成路线 （共 6 条）
反应条件
L-phenylalanine; (1S)-10-camphorsulfonic acid in acetonitrile T=25 - 70°C; asymmetric Robinson annulation; 120 h;
参考文献
Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Kim, Charles; Theodorakis, Emmanuel A.
Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7175 - 7190
反应条件
hexamethylimidazolium hexafluorophosphate; D-(+)-Phenylalanine; (1S)-10-camphorsulfonic acid in various solvent(s) T=20 - 70°C; Title compound not separated from byproducts;
参考文献
Nozawa, Masato; Akita, Tetsuya; Hoshi, Takashi; Suzuki, Toshio; Hagiwara, Hisahiro
Synlett, 2007 , # 4 p. 661 - 663
反应条件
1: 89 percent / Et3N / ethyl acetate / 12 h / 25 °C 2: 60 percent / D-CSA; L-Phe / acetonitrile / 120 h / 25 - 70 °C View Scheme
参考文献
Sakai, Hitoshi; Hagiwara, Hisahiro; Yoshiaki, Ito; Hoshi, Takashi; Suzuki, Toshio; Ando, Masayoshi
Tetrahedron Letters, 1999 , vol. 40, # 15 p. 2965 - 2968
反应条件
1: 89 percent / Et3N / ethyl acetate / 12 h / 25 °C 2: 60 percent / D-CSA; L-Phe / acetonitrile / 120 h / 25 - 70 °C View Scheme
参考文献
Sakai, Hitoshi; Hagiwara, Hisahiro; Yoshiaki, Ito; Hoshi, Takashi; Suzuki, Toshio; Ando, Masayoshi
Tetrahedron Letters, 1999 , vol. 40, # 15 p. 2965 - 2968
反应条件
perchloric acid; 2-aminoisovaleric acid; toluene-4-sulfonic acid; acetic acid Multistep reaction. Title compound not separated from byproducts;
参考文献
Paquette, Leo A.; Wang, Ting-Zhong; Sivik, Matthew R.
Journal of the American Chemical Society, 1994 , vol. 116, # 25 p. 11323 - 11334
反应条件
1: 97 percent / NaBH4 / methanol / 0.5 h / 0 °C
2: 77 percent / imidazole; DMAP / dimethylformamide / 12 h / 35 °C
View Scheme
参考文献
Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Theodorakis, Emmanuel A.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 6 p. 739 - 742
