(+)-六氢-3a-羟基-7a-甲基-1H-茚-1,5(6H)-二酮合成路线 （共 13 条）
反应条件
L-proline in N,N-dimethyl-formamide T=20°C; Hajos-Parrish-Eder-Sauer-Wiechert reaction; 24 h; Inert atmosphere; optical yield given as percent eestereoselective reaction;
参考文献
Zhu, Hui; Clemente, Fernando R.; Houk, K. N.; Meyer, Matthew P.
Journal of the American Chemical Society, 2009 , vol. 131, p. 1632 - 1633
反应条件
acetic acid in water T=20°C; Robinson Annulation; 48 h; Time; enantioselective reaction;
参考文献
Tetrahedron Letters, , vol. 54, # 24 p. 3101 - 3104
反应条件
in isopropyl alcohol
参考文献
Hoffmann-La Roche Inc.
Patent: US3975440 A1, 1976 ;
反应条件
L-proline in N,N-dimethyl-formamide T=50°C; 6.5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 108, # 9 p. 2353 - 2357
反应条件
1: 2-methyl-1,3-cyclo-pentanedione With L-proline in dimethyl sulfoxide T=15 - 25°C; 6 h; 2: methyl vinyl ketone in dimethyl sulfoxide T=15 - 25°C; asymmetric Robinson annulation; 145 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 29 p. 4887 - 4890
反应条件
L-proline in chloroform T=20°C; Hajos-Parrish reaction; 316 h; optical yield given as percent eeenantioselective reaction;
参考文献
de Arriba, Angel L. Fuentes; Simon, Luis; Raposo, Cesar; Alcazar, Victoria; Moran, Joaquin R.
Tetrahedron, 2009 , vol. 65, # 25 p. 4841 - 4845
反应条件
1: acetic acid / water / 16 h / 70 °C 2: L-proline / N,N-dimethyl-formamide / 16 h / 20 °C View Scheme
参考文献
MedChemComm, , vol. 4, # 11 p. 1439 - 1442
反应条件
1: triethylamine / dichloromethane / 12 h 2: acetic acid / water / 48 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 24 p. 3101 - 3104
反应条件
in chloroform-d1 T=0°C; Hajos-Parrish reaction; 2 h; Mechanism; enantioselective reaction;
参考文献
Tetrahedron, , vol. 65, # 25 p. 4841 - 4845
反应条件
toluene-4-sulfonic acid in toluene 5 h; Heating; Title compound not separated from byproducts.;
参考文献
Pedrosa, Rafael; Andres, Jose Maria; Manzano, Ruben; Perez-Lopez, Cesar
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3101 - 3104
