苯基(1-吡咯烷基)甲酮合成路线 （共 32 条）
反应条件
Lawesson's reagent in benzene
12 h; Ambient temperature;
参考文献
Smith, D. C.; Lee, S. W.; Fuchs, P. L.
Journal of Organic Chemistry, 1994 , vol. 59, # 2 p. 348 - 354
反应条件
n-butyllithium; naphthalene; lithium
1.) hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 6 h; -78 to 20 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Almena, Juan; Foubelo, Francisco; Yus, Miguel
Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3210 - 3215
反应条件
9-borabicyclo[3.3.1]nonane dimer in tetrahydrofuran; N-dodecane
T=25°C;
参考文献
Godjoian, Gayane; Singaram, Bakthan
Tetrahedron Letters, 1997 , vol. 38, # 10 p. 1717 - 1720
反应条件
2: 93 percent / 2N HCl / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Ramon, Diego J.; Yus, Miguel
Tetrahedron Letters, 1990 , vol. 31, # 26 p. 3763 - 3766
反应条件
1: 80 percent / methoxylation by anodic oxidation (C rods, (C2H5)4NOTs)
2: 87 percent / acetic acid; ethanol; H2O / Heating
View Scheme
参考文献
Shono, Tatsuya; Matsumura, Yoshihiro; Kanazawa, Takenobu
Tetrahedron Letters, 1983 , vol. 24, # 12 p. 1259 - 1262
反应条件
1: e-, tetraethylammonium p-toluenesulfonate / anodic oxidation
2: H+ / Heating
View Scheme
参考文献
Matsumura, Yoshihiro; Terauchi, Jun; Yamamoto, Takashi; Konno, Takashi; Shono, Tatsuya
Tetrahedron, 1993 , vol. 49, # 38 p. 8503 - 8512
反应条件
1: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; AgB(C6F5)4 / 1,2-dichloro-ethane / 16 h / 75 °C / Inert atmosphere
2: toluene-4-sulfonic acid / toluene / 16 h / 100 °C
3: methanol; naphthalene; sodium / ethylene glycol dimethyl ether / 2.08 h / -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
Hesp, Kevin D.; Bergman, Robert G.; Ellman, Jonathan A.
Organic Letters, 2012 , vol. 14, # 9 p. 2304 - 2307
反应条件
[bis(acetoxy)iodo]benzene; [Ru(p-cymene)(MesCO2)2]; trifluoroacetic acid; trifluoroacetic anhydride
T=120°C; 30 h;
参考文献
Thirunavukkarasu, Vedhagiri S.; Hubrich, Jonathan; Ackermann, Lutz
Organic Letters, 2012 , vol. 14, # 16 p. 4210 - 4213
反应条件
1: 80 percent / methoxylation by anodic oxidation (C rods, (C2H5)4NOTs)
2: 76 percent / ZnCl2 / xylene / Heating
View Scheme
参考文献
Shono, Tatsuya; Matsumura, Yoshihiro; Kanazawa, Takenobu
Tetrahedron Letters, 1983 , vol. 24, # 12 p. 1259 - 1262
反应条件
naphthalenyllithium
1) THF, -78 deg C, 7 h, 2) 20 deg C, overnight; Yield given. Multistep reaction;
参考文献
Ramon, Diego J.; Yus, Miguel
Journal of Organic Chemistry, 1991 , vol. 56, # 12 p. 3825 - 3831
