5-甲氧基-3,4-二氢-2H-1-萘酮合成路线 （共 55 条）
反应条件
potassium hydroxide; hydrazine hydrate in diethylene glycol
参考文献
Ando, Takashi; Yamawaki, Junko; Saito, Yoshimasa; Takai, Yoshio; Yamataka, Hiroshi
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 8 p. 2348 - 2356
反应条件
1: 98 percent / NaBH4 / ethanol / 12 h 2: NaH / toluene / 1 h / Heating 3: 55 percent / BBr3 / CH2Cl2 / 6.5 h / -78 - 20 °C View Scheme
参考文献
Banerjee; Poon; Laya; Azocar
Russian Journal of General Chemistry, 2003 , vol. 73, # 11 p. 1815 - 1820
反应条件
1: 1.) sodium borohydride, ethanol, 15 min., reflux 2.) p-toluenesulfonic acid, benzene, reflux 2: 78 percent / N-methylmorpholine N-oxide, osmium tetroxide / H2O; acetone; 2-methyl-propan-2-ol; CCl4 3: 97 percent / p-toluenesulfonic acid / benzene / 0.25 h / Heating View Scheme
参考文献
Hauser, Frank M.; Prasanna, Subbarao
Synthesis, 1980 , # 8 p. 621 - 623
反应条件
1: NaH / tetrahydrofuran 2: DDQ / dioxane 3: K2CO3 / acetone 4: NaH / tetrahydrofuran 5: CF3COOH / H2O 6: 85 percent / NaOAc / 4 h / 140 °C 7: 1.) CrO3, 2.) 48percent HBr / 1.) AcOH, View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 2 p. 289 - 292
反应条件
trichlorophosphate 1.) CH2Cl2, 27 deg C, 2 h, 2.) CH2Cl2, 27 deg C, 8 h; Yield given. Multistep reaction;
参考文献
Donkor; Devraj; Queener; Barrows; Gangjee
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1653 - 1661
反应条件
1: 1.) BF3*Et2O, 2.) pyridine, POCl3 / 1.) a) 60 deg C, 2 h, b) 90 deg C, 2 h, 2.) heating 2: sulfur, 5percent Pd/C / 2 h / 190 - 200 °C 3: 75 percent / NaCN / dimethylsulfoxide / 12 h / 160 - 170 °C View Scheme
参考文献
Tolbert, Laren M.; Haubrich, Jeanne E.
Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10593 - 10600
反应条件
hydrogen bromide; acetic acid 0.75 h; Heating;
参考文献
Valderrama; Pessoa-Mahana; Tapia
Synthetic Communications, 1992 , vol. 22, # 4 p. 629 - 639
反应条件
1: 99 percent / (S,S)-N-(p-tolylsulfonyl)-1,2-diphenylethylenediamine; HCO2H; Et3N / [RuCl2(ν6-mesitylene)]2 2: diphenyl phosphorazidate; DBU / toluene 3: H2 / Pd/C / methanol View Scheme
参考文献
Abate, Carmen; Niso, Mauro; Lacivita, Enza; Mosier, Philip D.; Toscano, Annamaria; Perrone, Roberto
Journal of Medicinal Chemistry, 2011 , vol. 54, # 4 p. 1022 - 1032
反应条件
1: Br2 / diethyl ether / 10 °C 2: NaBH4 / ethanol; tetrahydrofuran / 20 °C 3: p-TsOH / toluene / 120 °C View Scheme
参考文献
Buettelmann, Bernd; Alanine, Alexander; Bourson, Anne; Gill, Ramanjit; Heitz, Marie-Paule; Mutel, Vincent; Pinard, Emmanuel; Trube, Gerhard; Wyler, Rene
Chimia, 2004 , vol. 58, # 9 p. 630 - 633
反应条件
bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; cesium fluoride in toluene T=100°C; Inert atmosphere;
参考文献
Bouffard, Jean; Itami, Kenichiro
Organic Letters, 2009 , vol. 11, # 19 p. 4410 - 4413
