5-甲氧基-3,4-二氢-2H-1-萘酮合成路线 （共 55 条）
反应条件
bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; cesium fluoride in toluene
T=100°C; Inert atmosphere;
参考文献
Bouffard, Jean; Itami, Kenichiro
Organic Letters, 2009 , vol. 11, # 19 p. 4410 - 4413
反应条件
1: 77 percent / sodium hydride / diethyl ether / 12 h / Ambient temperature
2: sodium nitrite, acetic acid / CH2Cl2 / 0.5 h / 0 °C
3: zinc, acetic acid / 2 h
4: 92 percent / H2, conc. H2SO4 / 5percent palladium on carbon / acetic acid / 4 h / 2585.7 Torr
5: 86 percent / 3 N aq. HCl / 18 h / Heating
View Scheme
参考文献
Ye, Qizhuang; Grunewald, Gary L.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 478 - 486
参考文献
Bayer Aktiengesellschaft
Patent: US4868331 A1, 1989 ;
反应条件
1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 14 h / 0 - 25 °C / |Inert atmosphere
3: palladium on activated charcoal; hydrogen / methanol; chloroform / 20 h / 25 °C
View Scheme
参考文献
Akbaba, Yusuf; Akincioglu, Akin; Goecer, Huelya; Goeksu, Sueleyman; Guelcin, Ilhami; Supuran, Claudiu T.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 1 p. 35 - 42
反应条件
hydroxylamine hydrochloride; hydrogen; sodium acetate; palladium on activated charcoal
Multistep reaction;
参考文献
Perrone, Roberto; Berardi, Francesco; Leopolde, Marcello; Tortorella, Vincenzo; Fornaretto, Maria Gioia; Caccia, Carla; McArthur, Robert A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 16 p. 3195 - 3202
