反应条件
1: 4-hydroxyiodobenzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc in N,N-dimethyl-formamide
T=0°C; Negishi coupling reaction; Inert atmosphere;
2: (S)-N-Boc-2-(iodomethyl)pyrrolidine in N,N-dimethyl-formamide
T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
