1: 2-bromo-5-(4-dimethoxy-2,6-dimethylphenyl)pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: With zinc(II) chloride in tetrahydrofuran; hexane T=-78 - 20°C; 3: 2,6-Dibromopyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane Negishi coupling; 12 h; Heating;

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 1.2: zinc chloride / tetrahydrofuran; hexane / -78 - 20 °C 1.3: 62 percent / [Pd(PPh3)4] / tetrahydrofuran; hexane / 12 h / Heating 2.1: pyridinium hydrochloride View Scheme