甲基(2E,4E,6E,8E)-3,7-二甲基-9-(2,6,6-三甲基-1-环己烯基)壬-2,4,6,8-四烯酸酯合成路线 （共 32 条）
反应条件
1: 40 percent / 2,6-di-tert-butyl-4-methylpyridine / CH2Cl2 / 0 - 50 °C 2: 98 percent / Pd2(dba)3; AsPh3 / various solvent(s) / 0.5 h / 60 °C View Scheme
参考文献
Dominguez, Beatriz; Iglesias, Beatriz; De Lera, Angel R.
Tetrahedron, 1999 , vol. 55, # 52 p. 15071 - 15098
反应条件
1: 90 percent / I2 / CH2Cl2 / 0.17 h / 0 °C 2: 76 percent / Pd2(dba)3; AsPh3 / various solvent(s) / 3 h / 50 °C View Scheme
参考文献
Dominguez, Beatriz; Iglesias, Beatriz; De Lera, Angel R.
Tetrahedron, 1999 , vol. 55, # 52 p. 15071 - 15098
反应条件
1: 1.) ethylmagnesium bromide / 1.) THF, r.t., 1.5 h; 2.) THF, r.t., 1 h 2: 81 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 55 °C 3: 60 percent / LiAlH4, titanium trichloride, triethylamine / tetrahydrofuran; diethyl ether / 0.5 h / 50 °C 4: 1.) collidine, silver nitrate; 2.) silica gel / 1.) acetonitrile; 2.) column chromatography with hexane-ether View Scheme
参考文献
Solladie, G.; Berl, V.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 568 - 574
反应条件
1: 1.) ethylmagnesium bromide / 1.) THF, r.t., 1.5 h; 2.) THF, r.t., 1 h 2: 81 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 55 °C 3: 60 percent / LiAlH4, titanium trichloride, triethylamine / tetrahydrofuran; diethyl ether / 0.5 h / 50 °C 4: 1.) collidine, silver nitrate; 2.) silica gel / 1.) acetonitrile; 2.) column chromatography with hexane-ether View Scheme
参考文献
Solladie, G.; Berl, V.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 568 - 574
反应条件
1: 95 percent / Diisobuthylaluminium hydride / petroleum ether; hexane / 1 h / -60 - -20 °C 2: 98 percent / KCN, MnO2, AcOH / methanol / 12 h / Ambient temperature View Scheme
参考文献
Pardoen, J. A; Winkel, C; Mulder, P.P.J; Lugtenburg, J
Recueil: Journal of the Royal Netherlands Chemical Society, 1984 , vol. 103, # 4 p. 135 - 141
反应条件
1: 100 percent / 4-(dimethyilamino)pyridine / toluene / 20 h / Ambient temperature 2: 93 percent / DBN / toluene / 1.5 h / Heating 3: 95 percent / Diisobuthylaluminium hydride / petroleum ether; hexane / 1 h / -60 - -20 °C 4: 98 percent / KCN, MnO2, AcOH / methanol / 12 h / Ambient temperature View Scheme
参考文献
Pardoen, J. A; Winkel, C; Mulder, P.P.J; Lugtenburg, J
Recueil: Journal of the Royal Netherlands Chemical Society, 1984 , vol. 103, # 4 p. 135 - 141
参考文献
Curley, Robert W.; Fowble, John W.
Magnetic Resonance in Chemistry, 1989 , vol. 27, # 7 p. 707 - 709
Title/Abstract Full Text Show Details
Matsui; Kajiwara; Hatanaka; Waldmann; Schreier
Bioscience, Biotechnology and Biochemistry, 1994 , vol. 58, # 1 p. 140 - 145
参考文献
Wong, Corinne G.; Rando, Robert R.
Journal of the American Chemical Society, 1982 , vol. 104, # 25 p. 7374 - 7375
反应条件
1: zinc; diethyl ether; tetrahydrofuran / Hydrolyse und Dehydratisierung mit Hilfe von N-Jod-succinimid 2: diethyl ether 3: zinc; ethyl acetate; benzene 4: oxalic acid / unter vermindertem Druck View Scheme
参考文献
Karrer; Jucker; Schick
Helvetica Chimica Acta, 1946 , vol. 29, p. 704,710
反应条件
1: diethyl ether 2: zinc; ethyl acetate; benzene 3: oxalic acid / unter vermindertem Druck View Scheme
参考文献
Karrer; Jucker; Schick
Helvetica Chimica Acta, 1946 , vol. 29, p. 704,710
