1-(叔丁氧基羰基)-5-吲哚啉羧酸合成路线 （共 3 条）
反应条件
1: 2,3-dihydro-indole-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester With lithium hydroxide in tetrahydrofuran; water T=20°C; 24 h; 2: potassium hydrogensulfate in tetrahydrofuran; water
参考文献
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6747024 B1, 2004 ;
Location in patent: Page column 37 ;
反应条件
1: With sodium hydroxide in methanol; water 32 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2004/69792 A2, 2004 ;
Location in patent: Page 165 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-73°C; 0.25 h; 2: With carbon dioxide in tetrahydrofuran; hexane T=-73 - 20°C; 3 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/65351 A1, 2004 ;
Location in patent: Page 82-83 ;
