N-[2-(3-溴苯基)-2-氧代乙基]氨基甲酸1,1-二甲基乙酯合成路线 （共 2 条）
反应条件
1: 3-bromo-1-iodobenzene With tert.-butyl lithium in diethyl ether; pentane T=-78°C; 0.5 h; 2: N-(tert-butoxycarbonyl)glycine N'-methoxy-N'-methylamide in tetrahydrofuran; diethyl ether; pentane T=-78 - 0°C; 2 h; 3: With water; ammonium chloride in tetrahydrofuran; diethyl ether; pentane T=0°C;
参考文献
MERCK and CO., INC.
Patent: WO2007/136571 A1, 2007 ;
Location in patent: Page/Page column 45-46 ;
WO 2007/136571 A1
反应条件
1: 3-bromo-1-iodobenzene With tert.-butyl lithium in diethyl ether; pentane T=-78°C; 0.5 h; 2: N-(tert-butoxycarbonyl)glycine N'-methoxy-N'-methylamide in tetrahydrofuran; diethyl ether; pentane T=-78°C; 2 h;
参考文献
MERCK and CO., INC.
Patent: WO2003/87037 A1, 2003 ;
Location in patent: Page/Page column 69-70 ;
WO 03/087037 A1
