Boc-L-丙氨酸 N-丁二酰亚胺酯合成路线 （共 17 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran T=20°C; 2.5 h;
参考文献
Fujisawa, Tetsunori; Odake, Shinjiro; Ogawa, Yuji; Yasuda, Junko; Morita, Yasuo; Morikawa, Tadanori
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 2 p. 239 - 252
反应条件
in tetrahydrofuran T=20°C;
参考文献
Wallen, Erik A. A.; Christiaans, Johannes A. M.; Jarho, Elina M.; Forsberg, Markus M.; Venaelaeinen, Jarkko I.; Maennistoe, Pekka T.; Gynther, Jukka
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4543 - 4551
反应条件
triethylamine in 1,4-dioxane; dichloromethane
T=0 - 20°C; 16 h;
参考文献
Radyukhin, V. A.; Kazakova, N. A.; Filippovich, E. I.; Evstigneeva, R. P.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 2 p. 432 - 440,377 - 384
反应条件
in tetrahydrofuran
T=0 - 29°C; 29 h;
参考文献
Zhao, Nan; Ma, Yao; Liu, Gang
Chinese Chemical Letters, 2011 , vol. 22, # 12 p. 1443 - 1446
反应条件
triethylamine in acetonitrile
15 h; Ambient temperature; Yield given;
参考文献
Fukuda; Kobayashi; Yukimasa; Imada; Fujino; Azuma; Yamamura
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 8 p. 2215 - 2221
反应条件
1: 900 mg / NaHCO3 / acetonitrile; H2O
2: 83 percent / N-hydroxysuccinimide, DCC, 25 percent NH4OH / acetonitrile / 1 h
View Scheme
参考文献
Zemlyakov
Chemistry of Natural Compounds, 1998 , vol. 34, # 1 p. 78 - 79
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; N,N-dimethyl-formamide
T=22°C; 12.5 h;
参考文献
Curran, Timothy P.; Lesser, Adam B.; Yoon, Richard S.H.
Journal of Organometallic Chemistry, 2006 , vol. 691, # 26 p. 5560 - 5571
