Boc-L-异亮氨酸羟基琥珀酰亚胺酯合成路线 （共 6 条）
反应条件
dicyclohexyl-carbodiimide in ethyl acetate 16 h;
参考文献
Archiv der Pharmazie, , vol. 336, # 6-7 p. 300 - 309
反应条件
4-methyl-morpholine in acetonitrile
参考文献
Tetrahedron Letters, , vol. 26, # 14 p. 1721 - 1722
反应条件
triethylamine in 1,4-dioxane
参考文献
Miroshnikov,A.I. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1970 , vol. 40, # 2 p. 429 - 443,395 - 407
反应条件
1: triethylamine / 1,2-dimethoxy-ethane / 18 h / Ambient temperature 2: HCl (gas) / ethyl acetate / 0.33 h / -25 °C 3: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC), triethylamine / dimethylformamide / 20 h / Ambient temperature 4: tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 20 h / Ambient temperature View Scheme
参考文献
DeSolms; Giuliani; Guare; Vacca; Sanders; Graham; Wiggins; Darke; Sigal; Zugay; Emini; Schleif; Quintero; Anderson; Huff
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2852 - 2857
反应条件
1: 75 percent / triethylamine / 1,2-dimethoxy-ethane / 18 h / Ambient temperature 2: 86 percent / HCl (gas) / ethyl acetate / 0.33 h / -25 °C 3: 82 percent / 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC), triethylamine / dimethylformamide / 20 h / Ambient temperature 4: 98 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 20 h / Ambient temperature View Scheme
参考文献
DeSolms; Giuliani; Guare; Vacca; Sanders; Graham; Wiggins; Darke; Sigal; Zugay; Emini; Schleif; Quintero; Anderson; Huff
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2852 - 2857
反应条件
sodium hydrogencarbonate in ethanol; acetone
T=20°C; 16 h;
参考文献
Radau, Gregor; Schermuly, Sonja; Fritsche, Alexandra
Archiv der Pharmazie, 2003 , vol. 336, # 6-7 p. 300 - 309
