N-(1-氧代十二烷基)-L-谷氨酸(9CI)合成路线 （共 11 条）
反应条件
1: Wang resin-bound Fmoc-L-glutamic acid With piperidine in N,N-dimethyl-formamide T=20°C; 2: dodecanoyl chloride With N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 1 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 18 h;
参考文献
Phoon, Chee Wee; Somanadhan, Brinda; Heng, Sabrina Cher Hui; Ngo, Anna; Ng, Siew Bee; Butler, Mark S.; Buss, Antony D.; Sim, Mui Mui
Tetrahedron, 2004 , vol. 60, # 50 p. 11619 - 11628
反应条件
hydrogen; palladium on activated charcoal in methanol; acetic acid 10 h;
参考文献
Gaur, R. K.; Chauhan, V. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 405 - 408
反应条件
sodium hydroxide; triethylamine in water; 1,2-dichloro-ethane; acetone
反应条件
acylase I from pig kidney in water; glycerol T=37°C; pH=7.5; 66 h;
参考文献
Wada, Eiko; Handa, Masato; Imamura, Koreyoshi; Sakiyama, Takaharu; Adachi, Shuji; Matsuno, Ryuichi; Nakanishi, Kazuhiro
JAOCS, Journal of the American Oil Chemists' Society, 2002 , vol. 79, # 1 p. 41 - 46
反应条件
1: 85 percent / TEA, isobutyl chloroformate / tetrahydrofuran / 4 h / Ambient temperature 2: 72 percent / H2 / 10percent Pd-C / methanol; acetic acid / 10 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 405 - 408
反应条件
1: 85 percent / TEA, isobutyl chloroformate / tetrahydrofuran / 4 h / Ambient temperature 2: 72 percent / H2 / 10percent Pd-C / methanol; acetic acid / 10 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 405 - 408
反应条件
sodium hydroxide in methanol
参考文献
Chemistry - A European Journal, , vol. 17, # 12 p. 3429 - 3437
反应条件
potassium hydroxide T=0°C;
反应条件
acylase I from pig kidney; water in glycerol T=37°C; pH=7.5; 3 h; Equilibrium constant;
参考文献
JAOCS, Journal of the American Oil Chemists' Society, , vol. 79, # 1 p. 41 - 46
反应条件
acylase I from pig kidney; water in glycerol T=37°C; pH=7.5; 3 h; Equilibrium constant;
参考文献
Wada, Eiko; Handa, Masato; Imamura, Koreyoshi; Sakiyama, Takaharu; Adachi, Shuji; Matsuno, Ryuichi; Nakanishi, Kazuhiro
JAOCS, Journal of the American Oil Chemists' Society, 2002 , vol. 79, # 1 p. 41 - 46
