1-甲基-2-氧代-1,2-二氢吡啶-4-羧酸合成路线 （共 23 条）
反应条件
lithium hydroxide hydrate; water in methanol T=20°C; 2 h;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0229 ;
反应条件
sodium hydroxide; water; potassium hexacyanoferrate(III) T=50°C; 2 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259862 A1, 2007 ;
Location in patent: Page/Page column 28-29 ;
US 20070259862 A1
反应条件
alkaline solution; potassium hexacyanoferrate(III)
参考文献
Journal of Organic Chemistry, , vol. 24, p. 196
反应条件
1: toluene 2: sodium hydroxide; K3Fe(CN)6 / water View Scheme
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C 1.2: 0 - 20 °C 2.1: lithium hydroxide hydrate; water / methanol / 2 h / 20 °C View Scheme
反应条件
1.1: potassium hydroxide; water / 36 h / 0 °C / |Reflux 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C 2.2: 0 - 20 °C 3.1: lithium hydroxide hydrate; water / methanol / 2 h / 20 °C View Scheme
反应条件
alkaline solution; potassium hexacyanoferrate(III)
参考文献
Journal of Organic Chemistry, , vol. 24, p. 196
反应条件
1: SOCl2 3: K3<Fe(CN)6>; aqueous alkaline solution View Scheme
参考文献
Journal of Organic Chemistry, , vol. 24, p. 196
反应条件
2: K3<Fe(CN)6>; aqueous alkaline solution View Scheme
参考文献
Journal of Organic Chemistry, , vol. 24, p. 196
反应条件
water; silver(l) oxide
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 6, p. 615,617
