(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇合成路线 (共 9 条)
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3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
参考文献
Lathe, Richard Frank; Seckl, Jonathan Robert; Martin, Keith Frank; Wulfert, Ernst Arne
Patent: US2003/92692 A1, 2003 ;
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3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
反应条件
1: ethylene glycol; benzene; toluene-4-sulfonic acid-monohydrate 2: monoperoxyphthalic acid; diethyl ether 3: LiAlH4; THF 4: NaBH4; aqueous methanol View Scheme
参考文献
Iriarte et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6105,6108
→
3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
反应条件
1: monoperoxyphthalic acid; diethyl ether 2: LiAlH4; THF 3: NaBH4; aqueous methanol View Scheme
参考文献
Iriarte et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6105,6108
→
3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
反应条件
methanol; sodium tetrahydroborate
参考文献
Iriarte et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6105,6108
→
3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
反应条件
1: monoperoxyphthalic acid; diethyl ether; tetrahydrofuran 2: LiAlH4; THF View Scheme
参考文献
Iriarte et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6105,6108
→
3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
反应条件
1: LiAlH4; THF 2: NaBH4; aqueous methanol View Scheme
参考文献
Iriarte et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6105,6108
→
3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
反应条件
(microbiological transformation <Aspergillus carneus>);
参考文献
Laskin,A.I. et al.
Journal of Organic Chemistry, 1964 , vol. 29, p. 1333 - 1336
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3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
参考文献
Iriarte et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6105,6108
3398-11-6(7R,8R,9S,13S,14S,17S)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3,7,17-三醇
→
参考文献
Iriarte et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6105,6108