3,5-二甲基-4-溴吡唑合成路线 （共 20 条）
反应条件
in neat (no solvent) thermal decompn. (vac., 9 h, 165°C);
参考文献
Canadian Journal of Chemistry, , vol. 70, # 8 p. 2161 - 2173
参考文献
Journal of the American Chemical Society, , vol. 50, p. 2489
参考文献
Journal of Organic Chemistry, , vol. 22, p. 1688,1690, 1691
反应条件
diiodine pentaoxide in 1,4-dioxane T=85 - 90°C; 10 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 37, # 12 p. 1762 - 1766
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-78 - 20°C;
参考文献
Mendiola, Javier; Baeza, Alejandro; Alvarez-Builla, Julio; Vaquero, Juan J.
Journal of Organic Chemistry, 2004 , vol. 69, # 15 p. 4974 - 4983
反应条件
1: H2SO4 / heating for few hours 2: -50 to -40 deg C, then r.t. 3: triethylamine / hexane / 2 h / 35 - 60 °C View Scheme
参考文献
Sheludyakov, V. D.; Sheludyakova, S. V.; Kuznetsova, M. G.; Silkina, N. N.; Mironov, V. F.
J. Gen. Chem. USSR (Engl. Transl.), 1980 , vol. 50, # 4 p. 875 - 881,705 - 711
反应条件
1.1: 70 percent / KOH / ethanol / 1.5 h / 78 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -90 °C 2.2: trimethylborate / tetrahydrofuran; hexane / 0.5 h / -70 °C 2.3: 25 percent / aq. ammonium chloride / tetrahydrofuran; hexane / 1 h / 20 °C 3.1: 65 percent / molecular sieves 4 Angstroem / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Ivachtchenko, Alexandre V.; Kravchenko, Dmitry V.; Zheludeva, Valentina I.; Pershin, Dmitry G.
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 931 - 939
反应条件
1.1: 70 percent / KOH / ethanol / 1.5 h / 78 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -90 °C 2.2: trimethylborate / tetrahydrofuran; hexane / 0.5 h / -70 °C 2.3: 25 percent / aq. ammonium chloride / tetrahydrofuran; hexane / 1 h / 20 °C View Scheme
参考文献
Ivachtchenko, Alexandre V.; Kravchenko, Dmitry V.; Zheludeva, Valentina I.; Pershin, Dmitry G.
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 931 - 939
反应条件
pyridine 2 h; Heating;
参考文献
Heinisch, Gottfried; Holzer, Wolfgang; Pock, Sabine
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1829 - 1834
反应条件
potassium hydroxide in ethanol T=78°C; 1.5 h;
参考文献
Ivachtchenko, Alexandre V.; Kravchenko, Dmitry V.; Zheludeva, Valentina I.; Pershin, Dmitry G.
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 931 - 939
