反应条件
1.1: LDA / hexane; tetrahydrofuran / 2.5 h / -20 - 20 °C 1.2: 29 percent / hexane; tetrahydrofuran / 2 h / 20 °C 2.1: lithium diisopropylamide / tetrahydrofuran / 0.75 h / -78 °C 2.2: 92 percent / tetrahydrofuran / -78 - 20 °C 3.1: 91 percent / H2 / Pd/C / ethanol / 1 h / 20 °C / 775.72 Torr 4.1: 92 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / dimethylformamide / 12 h / 100 °C 5.1: 86 percent / trifluoroacetic acid / CH2Cl2 / 20 °C View Scheme
参考文献
Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424