1: 4-bromo-1(2H)-isoqionolinone With methyllithium in tetrahydrofuran; diethyl ether T=0°C; 0.166667 h; 2: With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=-78°C; 0.5 h; 3: carbon dioxide in tetrahydrofuran; diethyl ether; hexane Further stages.;

1: 66 percent / acetic acid anhydride / 1 h / Heating 2: 84 percent / NH3 / dioxane 3: 1) 1N NaOH / 1) dioxane, 1h View Scheme

1: 82 percent / acetic acid anhydride / 1 h / Heating 2: 84 percent / NH3 / dioxane 3: 1) 1N NaOH / 1) dioxane, 1h View Scheme

1: 84 percent / NH3 / dioxane 2: 1) 1N NaOH / 1) dioxane, 1h View Scheme

sodium hydroxide 1) dioxane, 1h; Yield given. Multistep reaction;

in diethyl ether; ethanol; N,N-dimethyl-formamide

ethanol; sulfuric acid