S-甲基-l-半胱氨酸甲酯盐酸盐合成路线 （共 8 条）
反应条件
methanol; acetyl chloride T=-15 - 20°C; 5 h;
参考文献
MERCK FROSST CANADA LTD.; BLACK, Cameron; BEAULIEU, Christian
Patent: WO2010/148488 A1, 2010 ;
Location in patent: Page/Page column 26 ;
WO 2010/148488 A1
反应条件
1: 24 h; Heating / reflux; 2: With hydrogenchloride in water T=20 - 40°C;
参考文献
ZAMBON GROUP S.p.A.
Patent: EP1053225 B1, 2004 ;
Location in patent: Page 5-6 ;
反应条件
thionyl chloride 2 h; Ambient temperature;
参考文献
Desimoni, Giovanni; Dusi, Guglielmo; Faita, Giuseppe; Quadrelli, Paolo; Righetti, PierPaolo
Tetrahedron, 1995 , vol. 51, # 14 p. 4131 - 4144
参考文献
Matteucci, Mizio; Bhalay, Gurdip; Bradley, Mark
Organic Letters, 2003 , vol. 5, # 3 p. 235 - 237
反应条件
hydrogenchloride; 3 A molecular sieve Heating;
参考文献
McNulty; Still
Synthetic Communications, 1992 , vol. 22, # 7 p. 979 - 985
反应条件
acetic acid T=90 - 100°C; 1 h;
参考文献
ZAMBON GROUP S.p.A.
Patent: EP1053225 B1, 2004 ;
Location in patent: Page 5-6 ;
反应条件
sodium tetrahydroborate in ethanol
参考文献
Lin; Dubois
Journal of Medicinal Chemistry, 1977 , vol. 20, # 3 p. 337 - 341
反应条件
TEA in N,N-dimethyl-formamide
T=60°C; 0.5 h; Yield given;
参考文献
McNulty; Still
Synthetic Communications, 1992 , vol. 22, # 7 p. 979 - 985
