5-(4-氯苯基)-2-呋喃甲醛合成路线 （共 19 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in ethylene glycol dimethyl ether; ethanol; water T=60°C; Suzuki-Miyaura Coupling; 2 h;
参考文献
Murasawa, Shinpei; Sato, Shinichi; Noguchi-Yachide, Tomomi; Hashimoto, Yuichi; Iuchi, Katsuya; Sodeoka, Mikiko; Dodo, Kosuke; Yokomatsu, Tsutomu; Aoyama, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6384 - 6393,10
反应条件
tetrabutylammomium bromide; potassium acetate; tri-cyclo-hexyl-phosphine; palladium dichloride in N,N-dimethyl-formamide T=110°C; 10 h;
参考文献
McClure; Glover; McSorley; Millar; Osterhout; Roschangar
Organic letters, 2001 , vol. 3, # 11 p. 1677 - 1680
反应条件
1: 4-chloro-aniline With hydrogenchloride; water; sodium nitrite T=0 - 5°C; 2: furfural With ammonium cerium(IV) nitrate in water T=20°C; 7 h;
参考文献
Subrahmanya Bhat; Shivarama Holla
Heterocyclic Communications, 2003 , vol. 9, # 6 p. 625 - 628
反应条件
hydrogenchloride; sodium nitrite in water; acetonitrile
参考文献
Norwich Eaton Pharmaceuticals, Inc.
Patent: US4882354 A1, 1989 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 1 h; Inert atmosphere;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Tetrahedron Letters, 2010 , vol. 51, # 19 p. 2657 - 2659
反应条件
palladium diacetate; caesium carbonate; triphenylphosphine in 1-methyl-pyrrolidin-2-one T=90°C; 1 h;
参考文献
Rao, Maddali L. N.; Awasthi, Dheeraj K.; Talode, Jalindar B.
Synlett, 2012 , vol. 23, # 13 p. 1907 - 1912
反应条件
CuCl2*2H2O in water; dimethyl sulfoxide T=24 - 26°C; Meerwein arylation;
参考文献
Obushak; Lesyuk; Gorak, Yu. I.; Matiichuk
Russian Journal of Organic Chemistry, 2009 , vol. 45, # 9 p. 1375 - 1381
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethanol; toluene Suzuki coupling; 5 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 19 p. 2681 - 2683
反应条件
1: 53 percent / EDCI; HOBt; DIPEA / dimethylformamide / 0 - 20 °C 2: 68 percent / LAH / tetrahydrofuran / 4 h / -30 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 8 p. 1850 - 1864
反应条件
CuCl2·2H2O in water; acetone T=20°C; 12 h;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 61, # 46 p. 10858 - 10863
