5-甲基-3-羰基己酸乙酯合成路线 （共 29 条）
反应条件
sodium hydride in tetrahydrofuran T=20 - 25°C; 4 h; Heating / reflux;
参考文献
Generics [UK] Limited; Mylan India Private Limted
Patent: US2010/324139 A1, 2010 ;
Location in patent: Page/Page column 11 ;
反应条件
1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in acetonitrile T=10 - 25°C; 2.5 h; 2: 3-methyl-butyryl chloride With triethylamine in acetonitrile T=0 - 25°C; 18 h;
参考文献
Pfizer Inc
Patent: US2008/125408 A1, 2008 ;
Location in patent: Page/Page column 8; 9 ;
反应条件
hydrogenchloride in dichloromethane; ammonia; water; toluene
参考文献
Lonza Ltd.
Patent: US4545934 A1, 1985 ;
反应条件
1: α,β-diketo ethyl butyrate With sodium hydride in tetrahydrofuran T=0°C; 0.166667 h; 2: With n-butyllithium in tetrahydrofuran; hexane T=0°C; 3: 2-iodo-propane
参考文献
WO2010/120854 A1, ;
Page/Page column 134 ;
WO 2010/120854 A1
反应条件
1: ethyl acetate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-70°C; 0.5 h; 2: 3-methyl-butyryl chloride in tetrahydrofuran; hexane T=-70°C; 0.666667 h;
参考文献
Baraldi, Patricia T.; Zarbin, Paulo H.G.; Vieira, Paulo C.; Correa, Arlene G.
Tetrahedron Asymmetry, 2002 , vol. 13, # 6 p. 621 - 624
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; 3-methyl-butyryl chloride With pyridine in dichloromethane T=0 - 20°C; 2: ethanol 4 h; Heating;
参考文献
Davis, Jessica M.; Truong, Anh; Hamilton, Andrew D.
Organic Letters, 2005 , vol. 7, # 24 p. 5405 - 5408
反应条件
copper(II) sulfate T=20°C; 24 h;
参考文献
Liao, Mingyi; Wang, Jianbo
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8859 - 8861
反应条件
1: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, overnight 2: H2 / 10percent Pd/C / ethanol / 4 h / 60 - 65 °C / 760 Torr 3: AcOH, H2O / 3 h / 40 - 45 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 324 - 346
反应条件
1: polystyrene-supported α-seleno acetate, loading 1.64 mmol/g (COOH) With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: isovaleraldehyde in tetrahydrofuran T=-78 - 20°C; 2.5 h; 3: With dihydrogen peroxide in tetrahydrofuran T=20°C;
参考文献
Synlett, , # 10 p. 1547 - 1548
反应条件
1: 60 percent / ethanol / 2 h / Heating 2: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, overnight 3: H2 / 10percent Pd/C / ethanol / 4 h / 60 - 65 °C / 760 Torr 4: AcOH, H2O / 3 h / 40 - 45 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 324 - 346
