Z-n-(n-beta-boc-氨基乙基)-gly-oh合成路线 （共 12 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 18 h;
参考文献
POLYPHOR AG; OBRECHT, Daniel; ERMERT, Philipp; OUMOUCH, Said; PIETTRE, Arnaud; GOSALBES, Jean-François; THOMMEN, Marc
Patent: WO2013/139697 A1, 2013 ;
Location in patent: Page/Page column 129 ;
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Nielsen, Peter E.
Patent: US6300318 B1, 2001 ;
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Buchardt, deceased; Ole; Buchardt, legal representative; by Dorte; Egholm; Michael; Nielsen; Peter Eigil; Berg; Rolf Henrik
Patent: US5719262 A1, 1998 ;
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Hoffmann-La Roche Inc.
Patent: US4145337 A1, 1979 ;
反应条件
sodium hydroxide in ethanol T=20°C; pH=9 - 10; 5 h;
参考文献
Chen, Yu-Chen; Muhlrad, Andras; Shteyer, Arie; Vidson, Marina; Bab, Itai; Chorev, Michael
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1624 - 1632
反应条件
1: 1 N aq. NaOH / ethanol / 20 °C 2: 2.3 g / 1 N aq. NaOH / ethanol / 5 h / 20 °C / pH 9 - 10 View Scheme
参考文献
Cooper, Daniel C.; Suggs, J. William
Tetrahedron Letters, 2012 , vol. 53, # 51 p. 6943 - 6945
反应条件
1: 48.3 percent / CH2Cl2 / 24 h / 20 °C 2: 1 N aq. NaOH / ethanol / 20 °C 3: 2.3 g / 1 N aq. NaOH / ethanol / 5 h / 20 °C / pH 9 - 10 View Scheme
参考文献
Chen, Yu-Chen; Muhlrad, Andras; Shteyer, Arie; Vidson, Marina; Bab, Itai; Chorev, Michael
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1624 - 1632
反应条件
1: pyridine / 20 °C 2: aq. NaOH View Scheme
参考文献
POLYPHOR AG; OBRECHT, Daniel; ERMERT, Philipp; OUMOUCH, Said; PIETTRE, Arnaud; GOSALBES, Jean-François; THOMMEN, Marc
Patent: WO2013/139697 A1, 2013 ;
反应条件
1: hydrogenchloride / diethyl ether / 1 h / 0 °C / |Inert atmosphere 2: triethylamine / toluene / 2 h / |Inert atmosphere 3: sodium hydroxide; water / methanol / 2 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Cooper, Daniel C.; Suggs, J. William
Tetrahedron Letters, 2012 , vol. 53, # 51 p. 6943 - 6945
反应条件
1: pyridine / 20 °C 2: aq. NaOH View Scheme
参考文献
Hudson; Tse
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 5-8 p. 1023 - 1027
