5-甲基异恶唑-3-甲酸合成路线 （共 25 条）
参考文献
Gazzetta Chimica Italiana, , vol. 78, p. 622,628
Atti X. Congr. int. Chim. Rom, , p. Bd. 3, S. 110, 118
参考文献
Chemische Berichte, , vol. 24, p. 3908
Chemische Berichte, , vol. 42, p. 60
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 26°C; 2: With acetic acid in tetrahydrofuran
参考文献
GLENMARK PHARMACEUTICAL S.A.; GHARAT, Laxmikant, Atmaram; NARAYANA, Lakshminarayana; YADAV, Pravin, Sabhajit; KHAIRATKAR-JOSHI, Neelima; BAJPAI, Malini
Patent: WO2011/132048 A1, 2011 ;
Location in patent: Page/Page column 40 ;
WO 2011/132048 A1
反应条件
thionyl chloride in N,N-dimethyl-formamide; toluene 5 h; Reflux;
参考文献
Jackson, Patrice L.; Hanson, Clive D.; Farrell, Alanna K.; Butcher, Raymond J.; Stables, James P.; Eddington, Natalie D.; Scott
European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 42 - 51
反应条件
hydrazine; copper; acetaldehyde
参考文献
Cusmano
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 240,244
参考文献
Zoepfchen
Diss. <Kiel 1899> S. 17, 29,
反应条件
1: copper-powder; ethanone; N2H2+H2O 2: unter Einleiten von HCl View Scheme
参考文献
Cusmano
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 240,244
反应条件
sodium nitrate; sulfuric acid T=50°C; 8 h;
参考文献
Trukhacheva; Levina; Grigor'ev; Arzamastsev; Dalinger; Vatsadze; Popova; Shevelev; Granik
Russian Chemical Bulletin, 2005 , vol. 54, # 12 p. 2813 - 2819
参考文献
Cusmano
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 86,88
参考文献
Cusmano
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 240,244
