反应条件
1.1: 11 g / bis-2-oxo-3-oxazolidinyl phosphinic chloride; Et3N / CH2Cl2 / 0 - 20 °C 2.1: 58 percent / Et3N*HCl / xylene / 3 h / Heating 3.1: lithium bis(trimethylsilyl)amide / dimethylformamide; tetrahydrofuran / 0.5 h / -10 °C 3.2: 61 percent / dimethylformamide; tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Sternfeld, Francine; Carling, Robert W.; Jelley, Richard A.; Ladduwahetty, Tamara; Merchant, Kevin J.; Moore, Kevin W.; Reeve, Austin J.; Street, Leslie J.; O'Connor, Desmond; Sohal, Bindi; Atack, John R.; Cook, Susan; Seabrook, Guy; Wafford, Keith; Tattersall, F. David; Collinson, Neil; Dawson, Gerard R.; Castro, Jose L.; MacLeod, Angus M.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 9 p. 2176 - 2179