2-甲基-1H-吲哚-4-羧酸合成路线 （共 3 条）
反应条件
sodium hydroxide in 1,4-dioxane; methanol; water T=60°C; 16 h;
参考文献
Torisu, Kazuhiko; Kobayashi, Kaoru; Iwahashi, Maki; Egashira, Hiromu; Nakai, Yoshihiko; Okada, Yutaka; Nanbu, Fumio; Ohuchida, Shuichi; Nakai, Hisao; Toda, Masaaki
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 5 p. 505 - 519
反应条件
1: 2,6-lutidine / CH2Cl2 / 1 h / 0 °C 2: 100 percent / Et3N; Pd(PPh3)4 / dimethylformamide / 20 - 60 °C 3: 40 percent / aq. NaOH / methanol; dioxane / 16 h / 60 °C View Scheme
参考文献
Torisu, Kazuhiko; Kobayashi, Kaoru; Iwahashi, Maki; Egashira, Hiromu; Nakai, Yoshihiko; Okada, Yutaka; Nanbu, Fumio; Ohuchida, Shuichi; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4557 - 4562
反应条件
1: 100 percent / Et3N; Pd(PPh3)4 / dimethylformamide / 20 - 60 °C 2: 40 percent / aq. NaOH / methanol; dioxane / 16 h / 60 °C View Scheme
参考文献
Torisu, Kazuhiko; Kobayashi, Kaoru; Iwahashi, Maki; Egashira, Hiromu; Nakai, Yoshihiko; Okada, Yutaka; Nanbu, Fumio; Ohuchida, Shuichi; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4557 - 4562
