4-(5-(三氟甲基)-1,2,4-恶二唑-3基)苯甲酸合成路线 （共 6 条）
反应条件
in tetrahydrofuran T=20°C; 4 h;
参考文献
NOVARTIS AG; HEBACH, Christina; JOLY, Emilie; KALLEN, Joerg; TERNOIS, James Gilbert; TINTELNOT-BLOMLEY, Marina
Patent: WO2013/8162 A1, 2013 ;
Location in patent: Page/Page column 63 ;
反应条件
sodium hydroxide in methanol T=20°C; 16 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 3 p. 268 - 277
反应条件
pyridine 3 h; Reflux;
参考文献
Liu, Kun; Lu, Hong; Hou, Ling; Qi, Zhi; Teixeira, Catia; Barbault, Florent; Fan, Bo-Tao; Liu, Shuwen; Jiang, Shibo; Xie, Lan
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7843 - 7854
反应条件
1: 83 percent / H2NOH*HCl; NaHCO3 / methanol / 3 h / Heating 2: 74 percent / CH2Cl2 / 3 h / 20 °C 3: 2 N aq. NaOH / methanol / 16 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 3 p. 268 - 277
反应条件
1: 74 percent / CH2Cl2 / 3 h / 20 °C 2: 2 N aq. NaOH / methanol / 16 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 3 p. 268 - 277
反应条件
1: potassium carbonate; hydroxylamine hydrochloride; 8-hydroxy-quinoline / ethanol; water / 4 h / |Reflux 2: tetrahydrofuran / 4 h / 20 °C View Scheme
