9-beta-D-呋喃阿拉伯糖基-2,6-二氨基嘌呤合成路线 （共 16 条）
反应条件
1: 62 percent / dry H2S / pyridine / 15 h / 12 °C / sealed tube 2: 75 percent / Raney Ni / ethanol; H2O / 0.5 h / Heating 3: 67 percent / NH3 (g) / methanol / 10 h / 100 °C / sealed tube View Scheme
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
反应条件
1: 75 percent / Raney Ni / ethanol; H2O / 0.5 h / Heating 2: 67 percent / NH3 (g) / methanol / 10 h / 100 °C / sealed tube View Scheme
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
反应条件
1: phosphoryl chloride, N,N-diethylaniline / 0.08 h / Heating 2: 78 percent / NH3 (g) / methanol / 8 h / 100 °C / sealed tube View Scheme
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
反应条件
(per)acetylperoxyboric acid; acetic anhydride 1.) DMSO, r.t., 22 h; 2.) EtOH, cooling to 0 deg C; Yield given;
参考文献
Hansske, Fritz; Madej, Danuta; Robins, Morris J.
Tetrahedron, 1984 , vol. 40, # 1 p. 125 - 135
反应条件
sodium hydroxide; boron trichloride 1.) CH2Cl2; Multistep reaction;
参考文献
Ross, Bruce S.; Springer, Robert H.; Sprankle, Kelly G.; Vasquez, Guillermo
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1645 - 1647
反应条件
1: adenosine deaminase / 72 h / 37 °C / phosphate buffer, pH 7-7.5 2: 1.) TMSCl, pyridine, 3.) NH4OH 3: TsOH / dioxane 4: DMAP / CH2Cl2 5: TBAF / tetrahydrofuran 6: Dowex-50 / methanol 7: NH4OH / 24 h / 55 °C View Scheme
参考文献
Ross, Bruce S.; Springer, Robert H.; Sprankle, Kelly G.; Vasquez, Guillermo
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1645 - 1647
