2-[2-(二甲基氨基)乙基]-1-茚满酮合成路线 （共 5 条）
反应条件
benzophenone; potassium tert-butylate in benzene 18 h; Heating / reflux;
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2005/97093 A1, 2005 ;
Location in patent: Page/Page column 32-33 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 6.5 h; Heating / reflux; 2: With sodium hydroxide; water T=20°C; 0.5 h;
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2005/97093 A1, 2005 ;
Location in patent: Page/Page column 32-33 ;
反应条件
PPA T=140 - 150°C; 0.333333 h;
参考文献
Boehme, Thomas M.; Keim, Christine; Kreutzmann, Kai; Linder, Matthias; Dingermann, Theo; Dannhardt, Gerd; Mutschler, Ernst; Lambrecht, Guenter
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 856 - 867
反应条件
1: 77 percent / aq. NaOH / ethanol / 4 h / Heating 2: 41 percent / polyphosphoric acid / 0.33 h / 140 - 150 °C View Scheme
参考文献
Boehme, Thomas M.; Keim, Christine; Kreutzmann, Kai; Linder, Matthias; Dingermann, Theo; Dannhardt, Gerd; Mutschler, Ernst; Lambrecht, Guenter
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 856 - 867
反应条件
1.1: NaH / toluene / 1 h / Heating 1.2: 85 percent / toluene / 6 h / Heating 2.1: 77 percent / aq. NaOH / ethanol / 4 h / Heating 3.1: 41 percent / polyphosphoric acid / 0.33 h / 140 - 150 °C View Scheme
参考文献
Boehme, Thomas M.; Keim, Christine; Kreutzmann, Kai; Linder, Matthias; Dingermann, Theo; Dannhardt, Gerd; Mutschler, Ernst; Lambrecht, Guenter
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 856 - 867
